Katsumata K, Katsumata K, Katsumata Y
Katsumata Hospital, Nagoya, Japan.
Horm Metab Res. 1992 Nov;24(11):508-10. doi: 10.1055/s-2007-1003376.
This study demonstrated that 20 mg/kg of the Ca2+ channel blocker, diltiazem hydrochloride, administered by intraperitoneal injection 15 min before 200 mg/kg of alloxan given by the same route to induce diabetes, served to suppress disease onset completely in rats. Even though 48-h fasting promoted the onset of alloxan diabetes, 40 mg/kg of diltiazem hydrochloride completely prevented the occurrence of diabetes induced by intraperitoneal injection of 200 mg/kg of alloxan. Forty mg/kg of the same agent, however, failed to prevent the onset of diabetes induced by the intravenous injection of streptozotocin (50 mg/kg). From the fact that Ca2+ channel blockers such as nicardipine, verapamil and bepridil have a similar suppressive effect on the occurrence of alloxan diabetes, one may readily infer that this action is characteristic of Ca2+ channel blockers. Moreover, the results suggest the close connection of Ca2+ in the occurrence of alloxan diabetes in rats.
本研究表明，在通过相同途径腹腔注射200mg/kg四氧嘧啶诱导糖尿病前15分钟，腹腔注射20mg/kg的钙离子通道阻滞剂盐酸地尔硫䓬，可完全抑制大鼠疾病发作。尽管48小时禁食会促进四氧嘧啶糖尿病的发作，但40mg/kg的盐酸地尔硫䓬可完全预防腹腔注射200mg/kg四氧嘧啶诱导的糖尿病的发生。然而，40mg/kg的同一药物未能预防静脉注射链脲佐菌素（50mg/kg）诱导的糖尿病发作。鉴于尼卡地平、维拉帕米和苄普地尔等钙离子通道阻滞剂对四氧嘧啶糖尿病的发生具有类似的抑制作用，人们可能很容易推断出这种作用是钙离子通道阻滞剂的特征。此外，结果表明钙离子与大鼠四氧嘧啶糖尿病的发生密切相关。
