Slotnick B, Bisulco S
Department of Psychology, American University, Washington, DC 20016, USA.
Neuroscience. 2003;121(2):451-7. doi: 10.1016/s0306-4522(03)00402-0.
Rats with lesions of dorsal and dorsolateral bulbar sites known to be differentially responsive to carvone enantiomers were tested for their ability to detect (+)-carvone, to discriminate between (+)-carvone from (-)-carvone, and to discriminate (+)-carvone from mixtures of both enantiomers after they had been pre-trained or not pre-trained on these tasks prior to surgery. In postoperative tests, rats pre-trained on the enantiomer discrimination problems made somewhat fewer errors than those not pre-trained, but experimental rats performed as well as controls (those that had one intact olfactory bulb) within both conditions and on each task. These results indicate that removal of most bulbar sites known to be differentially responsive to carvone enantiomers and the consequent disruption of normal patterns of bulbar input produced in response to carvones are largely without effect on the ability of rats to discriminate between these odors.
已知对香芹酮对映体有不同反应的延髓背侧和背外侧部位有损伤的大鼠，在手术前是否接受过这些任务的预训练的情况下，测试它们检测（+）-香芹酮的能力、区分（+）-香芹酮和（-）-香芹酮的能力，以及区分（+）-香芹酮与两种对映体混合物的能力。在术后测试中，在对映体辨别问题上接受过预训练的大鼠比未接受预训练的大鼠犯错略少，但在两种条件下以及每项任务中，实验大鼠的表现与对照组（有一个完整嗅球的大鼠）一样好。这些结果表明，去除大多数已知对香芹酮对映体有不同反应的延髓部位以及由此导致的对香芹酮反应产生的正常延髓输入模式的破坏，在很大程度上不会影响大鼠区分这些气味的能力。
