Manfredi Roberto, Calza Leonardo, Chiodo Francesco
Division of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Bologna, S. Orsola Hospital, Via Massarenti 11, I-40138 Bologna, Italy.
Int J Antimicrob Agents. 2003 Oct;22(4):449-52. doi: 10.1016/s0924-8579(03)00113-4.
The frequency, the microbiology and clinical features of AIDS-related primary episodes and relapses of cryptococcosis, before and after the introduction of highly active antiretroviral therapy (HAART), were compared. The study covered 58 cases diagnosed before the introduction of HAART, and eight episodes since 1997. Because of negative cultures, we sought a sensitive laboratory assay such as detection of polysaccharide antigen. Despite later diagnosis, there was reduced disease mortality. Clinical suspicion for HIV-associated cryptococcosis should be maintained in immunocompromised subjects. The introduction of HAART has led to significant clinical and laboratory changes of HIV-related cryptococcosis.
比较了高效抗逆转录病毒疗法（HAART）引入前后艾滋病相关隐球菌病初次发作和复发的频率、微生物学及临床特征。该研究涵盖了HAART引入前诊断的58例病例，以及自1997年以来的8次发作。由于培养结果为阴性，我们寻求一种敏感的实验室检测方法，如多糖抗原检测。尽管诊断较晚，但疾病死亡率有所降低。免疫功能低下的患者仍应保持对HIV相关隐球菌病的临床怀疑。HAART的引入导致了HIV相关隐球菌病显著的临床和实验室变化。
