Sabbatani S, Manfredi R, Pavoni M, Consales A, Chiodo F
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S. Orsola Hospital, Bologna, Italy.
Mycopathologia. 2004 Aug;158(2):165-71. doi: 10.1023/b:myco.0000041904.71381.e3.
Although being a rare occurrence, brain cryptococcoma may represent an emerging issue, because of its relationship with a broadening range of risk factors, including malignancies, neutropenia, end-organ failure, bone marrow and solid-organ transplantation, and multiple underlying causes of primary-secondary immunodeficiency. A cerebral cryptococcoma in a chronic nephropathic HIV-negative subject with homocystinuria, completely cured with neurosurgery and voriconazole after fluconazole failure, is described.
尽管脑隐球菌瘤较为罕见，但由于其与越来越多的风险因素相关，包括恶性肿瘤、中性粒细胞减少、终末器官衰竭、骨髓和实体器官移植以及原发性-继发性免疫缺陷的多种潜在病因，它可能成为一个新出现的问题。本文描述了一名患有同型胱氨酸尿症的慢性肾病HIV阴性患者发生的脑隐球菌瘤，在氟康唑治疗失败后，通过神经外科手术和伏立康唑完全治愈。
