Oh Seung Jun, Moon Dae Hyuk, Lee Won Woo, Park Seong-Wook, Hong Myeong-Ki, Park Seung-Jung, Shin Dong-Ik, Lee Hee Kyung
Departments of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-2dong, Songpa-gu, Seoul 138-736, South Korea.
Appl Radiat Isot. 2003 Oct;59(4):225-30. doi: 10.1016/s0969-8043(03)00170-2.
We have developed an automated system for the preparation of highly concentrated 188Re-perrhenate, diethylenetriamine pentaacetic acid (DTPA) and mercaptoacetyltriglycine (MAG3). The three procedural steps include concentration of 188Re-perrhanerate, chelation and purification and sterilization. The steps are operated by a small micro-controller. The eluted 188Re-perrhenate of 15 GBq/18 ml from 37 GBq 188W/188Re-generator was concentrated to 1.2 ml in 10 +/- 0.5 min with a recovery yield of 95 +/- 1.5%. We obtained the highest radiochemical yield of 95.4 +/- 2.8% and 98.5 +/- 1.2% for 188Re-DTPA and MAG3 at the oil bath temperatures of 95-97 degrees C and 93-97 degrees C, respectively.
我们已经开发出一种自动化系统，用于制备高浓度的188铼过铼酸盐、二乙烯三胺五乙酸（DTPA）和巯基乙酰三甘氨酸（MAG3）。这三个程序步骤包括188铼过铼酸盐的浓缩、螯合以及纯化和灭菌。这些步骤由一个小型微控制器操作。从37GBq的188钨/188铼发生器中洗脱出来的15GBq/18ml的188铼过铼酸盐在10±0.5分钟内浓缩至1.2ml，回收率为95±1.5%。在油浴温度分别为95 - 97摄氏度和93 - 97摄氏度时，我们获得的188铼 - DTPA和MAG3的最高放射化学产率分别为95.4±2.8%和98.5±1.2%。
