Zhang X Zh, Wang X B, Zhou J M
Department of Chemistry, Beijing Normal University, Beijing 100875, People's Republic of China.
Appl Radiat Isot. 2003 Oct;59(4):231-5. doi: 10.1016/s0969-8043(03)00169-6.
A new isonitrile ligand 3,3,5-trimethyl cyclohexylisonitrile (TMCHI) and its copper salt [Cu(TMCHI)4BF4] were synthesized and characterized by IR and elemental analysis. 99mTc-TMCHI is prepared by direct labeling method with high RCP. In vitro protein binding in albumin, blood retention and biodistribution of 99mTc-TMCHI in mice indicated that it is mainly accumulated and maintained in blood with a high protein binding rate and low washout rate. The target/non-target ratios in mice are excellent and suggest its use as a cardiac blood pool agent.
