Bouquillon S, Coulais Y, Dartiguenave M, Tafani J A, Guiraud R
Laboratoire de Biophysique et de Médecine Nucléaire, Faculté de Médecine Toulouse-Purpan, France.
Nucl Med Biol. 1995 Jul;22(5):585-8. doi: 10.1016/0969-8051(95)00001-e.
An isonitrile ligand with a silicium component was synthesized and a copper salt of this ligand was then used to form a 99mTc complex. We evaluated the physicochemical characteristics of the complex and its biodistribution in rat. The chemical properties, i.e. lipophilic affinity and charge, were comparable to those of other 99mTc complexes formed with similar isonitrile compounds (99mTc-MIBI and 99mTc-TBI). In contrast, the tissue biodistribution of this new technetium complex differed markedly, as it was mainly taken up in the liver and not at all in the heart.
合成了一种含有硅成分的异腈配体，然后使用该配体的铜盐形成99mTc配合物。我们评估了该配合物的物理化学特性及其在大鼠体内的生物分布。其化学性质，即亲脂亲和力和电荷，与用类似异腈化合物形成的其他99mTc配合物（99mTc-MIBI和99mTc-TBI）相当。相比之下，这种新的锝配合物的组织生物分布明显不同，因为它主要在肝脏中摄取，而在心脏中完全不摄取。
