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[肾移植后发生的爱泼斯坦-巴尔病毒相关中枢神经系统平滑肌肉瘤:病例报告及文献复习]

[Epstein-Barr virus associated central nervous system leiomyosarcoma occurring after renal transplantation: case report and review of the literature].

作者信息

Tahri A, Noel G, Figuerella-Branger D, Goncalves A, Feuvret L, Jauffret E, Brun B, Mazeron J J, Baillet F

机构信息

Centre des tumeurs, groupe hospitalier Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75651 Paris, cedex 13, France.

出版信息

Cancer Radiother. 2003 Oct;7(5):308-13. doi: 10.1016/s1278-3218(03)00055-6.

Abstract

Central nervous system leiomyosarcomas are extremely rare, however, they became more frequent among immunodeficient patients, either in a patients infected with human immunodeficiency virus (HIV), or after organ transplantation. The data of the literature indicate that the infection by Epstein-Barr virus (EBV) plays a causal role in the development of these tumours but its precise role in the oncogenesis remains unresolved. We report a new case of EBV associated leiomyosarcoma of the left cavernous sinus occurring after renal transplantation. The epidemiological, clinical, pathological and therapeutic characteristics of these tumours are discussed.

摘要

中枢神经系统平滑肌肉瘤极为罕见,然而,在免疫缺陷患者中更为常见,这些患者或是感染了人类免疫缺陷病毒(HIV),或是接受了器官移植。文献数据表明,爱泼斯坦-巴尔病毒(EBV)感染在这些肿瘤的发生中起因果作用,但其在肿瘤发生中的精确作用仍未明确。我们报告了1例肾移植后发生的与EBV相关的左侧海绵窦平滑肌肉瘤新病例。并对这些肿瘤的流行病学、临床、病理及治疗特征进行了讨论。

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