Diamantopoulos Leonidas, Liu Xiaoshun, De Scheerder Ivan, Krams Rob, Li Shengiao, Van Cleemput Johan, Desmet Walter, Serruys Patrick W
Cardiology Dept., University Gasthuisberg, Leuven, Belgium.
Eur Heart J. 2003 Oct;24(19):1788-95. doi: 10.1016/s0195-668x(03)00440-8.
The purpose of this study was to investigate the relation between acute coronary flow reduction and arterial wall temperature.
Five pigs with normal coronary arteries were catheterized. Arterial wall temperature was studied with a thermographic system that uses a 4-thermistor sensor tip. Flow velocity was studied at the same time and place with the temperature measurements, using a Doppler wire. In order to modify the coronary flow, a balloon was gradually inflated proximally to the thermographic sensors. Temperature differences and flow velocities were simultaneously recorded. Flow velocities above an average peak velocity (APV) of 9 cm/s were associated with unaffected temperature measurements. At flow velocities around 4 cm/s, the wall temperature was increased (deltaT=0.015+/-0.005 degrees C, P approximately 0.05), following the heart-rate. When flow velocity dropped further below this value, the local wall temperature was logarithmically increased to a maximum value observed at total vessel occlusion (deltaT=0.188+/-0.023 degrees C, P<0.001).
The reduction of coronary flow has an effect on the arterial wall temperature. This effect however, appears only below a critical threshold of APV and in a logarithmic fashion. Above this threshold, temperature measurements should be unaffected from flow reductions and related to the regional temperature heterogeneity.
本研究旨在探讨急性冠状动脉血流减少与动脉壁温度之间的关系。
对5只冠状动脉正常的猪进行导管插入术。使用带有4个热敏电阻传感器尖端的热成像系统研究动脉壁温度。在测量温度的同一时间和地点，使用多普勒导丝研究血流速度。为了改变冠状动脉血流，在热成像传感器近端逐渐充盈球囊。同时记录温度差异和血流速度。平均峰值速度（APV）高于9 cm/s的血流速度与未受影响的温度测量结果相关。在血流速度约为4 cm/s时，壁温随心率升高（ΔT = 0.015±0.005℃，P约为0.05）。当血流速度进一步降至该值以下时，局部壁温呈对数增加，直至血管完全闭塞时达到最大值（ΔT = 0.188±0.023℃，P<0.001）。
冠状动脉血流减少对动脉壁温度有影响。然而，这种影响仅在APV的临界阈值以下且呈对数方式出现。高于该阈值时，温度测量应不受血流减少的影响，而与局部温度异质性有关。
