Verheye Stefan, De Meyer Guido R Y, Krams Rob, Kockx Mark M, Van Damme Luc C A, Mousavi Gourabi Babak, Knaapen Michiel W M, Van Langenhove Glenn, Serruys Patrick W
Cardiovascular Translational Research Institute, Antwerp, Belgium.
Eur Heart J. 2004 Jan;25(2):158-65. doi: 10.1016/j.ehj.2003.10.023.
To investigate safety, feasibility, and injurious effect on endothelial cells of a thermography catheter as well as effect of flow on measured temperature in non-obstructive arteries.
Safety and feasibility were tested in both rabbit aortas and pig coronary arteries. Evaluation of endothelial damage by the catheter (acute, 7 and 14 days) was performed in pig coronaries using Evans Blue, scanning electron microscopy (SEM) and Factor-VIII antibody and compared with normal arteries and arteries that underwent intravascular ultrasound (IVUS). The effect of flow on temperature heterogeneity was analysed both in vitro and in vivo conditions. All procedures were successful without any adverse events; intra- and inter-operator variability was low. Intracoronary use of the catheter was associated with acute but reversible de-endothelialization, paralleling the findings associated with IVUS use. Changes in flow velocities under physiologic flow conditions did not significantly influence the temperature differences measured both in vitro and in vivo; temperature heterogeneity was more pronounced in absence of flow.
Intracoronary thermography using a dedicated catheter is safe and feasible with a similar degree of de-endothelialization as IVUS. Temperature heterogeneity remained unchanged under normal physiologic flow conditions allowing clinical use of thermography.
研究热成像导管的安全性、可行性及其对内皮细胞的损伤作用，以及血流对非阻塞性动脉中测量温度的影响。
在兔主动脉和猪冠状动脉中测试了安全性和可行性。使用伊文思蓝、扫描电子显微镜（SEM）和因子VIII抗体对猪冠状动脉中导管造成的内皮损伤（急性、7天和14天）进行评估，并与正常动脉和接受血管内超声（IVUS）检查的动脉进行比较。在体外和体内条件下分析了血流对温度异质性的影响。所有操作均成功，无任何不良事件发生；操作者内和操作者间的变异性较低。冠状动脉内使用导管与急性但可逆的内皮剥脱有关，这与IVUS使用的相关发现相似。生理血流条件下流速的变化对体外和体内测量的温度差异没有显著影响；无血流时温度异质性更明显。
使用专用导管进行冠状动脉热成像安全可行，内皮剥脱程度与IVUS相似。在正常生理血流条件下温度异质性保持不变，允许热成像在临床中使用。
