Yip Chee-Chew, Kersten Robert C, McCulley Timothy J, Ballard Edgar T, Kulwin Dwight R
Department of Ophthalmology, The Cincinnati Eye Institute and The University of Cincinnati College of Medicine, Barrett Center-0670, 242 Goodman Street, Cincinnati, OH 45219-2316, USA.
Ophthalmology. 2003 Oct;110(10):1996-9. doi: 10.1016/S0161-6420(03)00478-0.
We describe the occurrence of maxillary and orbital osteogenic sarcoma in a child after treatment of contralateral orbital rhabdomyosarcoma with external beam radiation and chemotherapy.
Interventional case report.
Treatment of a maxillary and orbital rhabdomyosarcoma with surgical resection, systemic chemotherapy, and local radiation.
Occurrence and histology of secondary malignancy after orbital radiation.
An eleven year-old male presented for evaluation of left facial swelling, occurring ten years after successful treatment of a right orbital embryonal rhabdomyosarcoma with chemotherapy and 5040 cGY of external beam radiation. Computerized tomography demonstrated a mass involving the left maxillary sinus and orbital floor. Biopsy demonstrated osteogenic sarcoma. Despite attempted total excision with radical maxillectomy, resection margins were found to have microscopic extension of the tumor. Postoperatively he was treated with systemic chemotherapy and local radiation. Eight months postoperatively he remains alive despite local progression.
Osteogenic sarcoma can occur as a secondary malignancy years after the successful treatment of orbital rhabdomyosarcoma with external beam radiation and chemotherapy. After orbital radiation, subjects should undergo routine lifelong examinations.
我们描述了一名儿童在接受对侧眼眶横纹肌肉瘤的外照射放疗和化疗后发生上颌骨及眼眶骨肉瘤的情况。
介入性病例报告。
采用手术切除、全身化疗和局部放疗治疗上颌骨及眼眶横纹肌肉瘤。
眼眶放疗后继发性恶性肿瘤的发生情况及组织学特征。
一名11岁男性因左侧面部肿胀前来评估，其右侧眼眶胚胎性横纹肌肉瘤经化疗及5040 cGY外照射放疗成功治疗10年后出现该症状。计算机断层扫描显示左侧上颌窦和眶底有肿物。活检显示为骨肉瘤。尽管尝试行根治性上颌骨切除术进行全切，但切除边缘仍有肿瘤的显微镜下扩展。术后他接受了全身化疗和局部放疗。术后8个月，尽管有局部进展，但他仍然存活。
在眼眶横纹肌肉瘤成功接受外照射放疗和化疗数年之后，骨肉瘤可作为继发性恶性肿瘤发生。眼眶放疗后，患者应接受终身常规检查。
