通过印片细胞学分析检测睑皮脂腺癌的结膜上皮内浸润。
Detection by impression cytologic analysis of conjunctival intraepithelial invasion from eyelid sebaceous cell carcinoma.
作者信息
Sawada Yu, Fischer Jeffrey L, Verm Alan M, Harrison Andrew R, Yuan Ching, Huang Andrew J W
机构信息
Department of Ophthalmology, University of Minnesota, 516 Delaware Street SE, 9th Floor, Minneapolis, MN 55455, USA.
出版信息
Ophthalmology. 2003 Oct;110(10):2045-50. doi: 10.1016/S0161-6420(03)00657-2.
OBJECTIVE
To demonstrate that conjunctival impression cytologic analysis can detect conjunctival intraepithelial invasion from sebaceous cell carcinoma of the eyelid.
DESIGN
Observational case series with cytopathologic correlation.
PARTICIPANTS
Four patients with unilateral blepharoconjunctivitis and biopsy-proven sebaceous cell carcinoma.
METHODS
Impression cytologic analysis specimens were taken from the suspicious area of the bulbar conjunctiva of each patient. Staining of the specimens was performed with a modified Papanicolaou stain.
MAIN OUTCOME MEASURE
Observation of the abnormal tumor cells in the collected specimens by bright field microscope.
RESULTS
The technique of impression cytologic analysis allowed collection and identification of abnormal tumor cells with characteristic cytoplasmic vacuoles.
CONCLUSIONS
Conjunctival impression cytologic analysis successfully detected the ocular surface sebaceous carcinoma cells from the eyelid. However, full-thickness biopsies are necessary to confirm the diagnosis. Judicious use of impression cytologic analysis may facilitate the detection and diagnosis of this invasive tumor.
目的
证明结膜印片细胞学分析能够检测出眼睑皮脂腺癌的结膜上皮内浸润。
设计
具有细胞病理学相关性的观察性病例系列。
参与者
4名单侧睑结膜炎且经活检证实为皮脂腺癌的患者。
方法
从每位患者球结膜的可疑区域采集印片细胞学分析标本。标本采用改良巴氏染色法染色。
主要观察指标
通过明视野显微镜观察所采集标本中的异常肿瘤细胞。
结果
印片细胞学分析技术能够采集并识别出具有特征性胞质空泡的异常肿瘤细胞。
结论
结膜印片细胞学分析成功检测出了来自眼睑的眼表皮脂腺癌细胞。然而，需要进行全层活检以确诊。合理使用印片细胞学分析可能有助于这种浸润性肿瘤的检测和诊断。
Zotero 插件