Kunkel Eric J, Butcher Eugene C
Bioseek, Inc., Burlingame, California 94010, USA.
Nat Rev Immunol. 2003 Oct;3(10):822-9. doi: 10.1038/nri1203.
Recent studies indicate that chemoattractant cytokines (chemokines), together with tissue-specific adhesion molecules, coordinate the migration of antibody-secreting cells (ASCs) from their sites of antigen-driven differentiation in lymphoid tissues to target effector tissues. Developing ASCs downregulate the expression of receptors for lymphoid tissue chemokines and selectively upregulate the expression of chemokine receptors that might target the migration of IgA ASCs to mucosal surfaces, IgG ASCs to sites of tissue inflammation and both types of ASC to the bone marrow - an important site for serum antibody production. By directing plasma-cell homing, chemokines might help to determine the character and efficiency of mucosal, inflammatory and systemic antibody responses.
近期研究表明，趋化因子细胞因子（趋化因子）与组织特异性黏附分子共同协作，协调抗体分泌细胞（ASC）从其在淋巴组织中抗原驱动分化的位点迁移至靶效应组织。正在发育的ASC下调淋巴组织趋化因子受体的表达，并选择性地上调趋化因子受体的表达，这些趋化因子受体可能靶向IgA ASC向黏膜表面的迁移、IgG ASC向组织炎症部位的迁移以及两种类型的ASC向骨髓（血清抗体产生的重要位点）的迁移。通过引导浆细胞归巢，趋化因子可能有助于确定黏膜、炎症和全身抗体反应的特征及效率。
