Michaëlsson G, Juhlin L, Ljunghall K
Br J Dermatol. 1977 Nov;97(5):561-6. doi: 10.1111/j.1365-2133.1977.tb14136.x.
With a double-blind technique, the effects of oral zinc and tetracyclines were compared in 37 patients with moderate and severe acne. No difference in effect between the treatments was seen and no side-effects were noted in any group. After 12 weeks of treatment, the average decrease in the acne score was about 70% in both groups.
采用双盲技术，对37例中度和重度痤疮患者口服锌和四环素的效果进行了比较。两种治疗方法在疗效上没有差异，且任何一组均未观察到副作用。治疗12周后，两组的痤疮评分平均下降约70%。
