Mayxay Mayfong, Newton Paul N, Khanthavong Maniphono, Tiengkham Pongvongsa, Phetsouvanh Rattanaxay, Phompida Samlane, Brockman Alan, White Nicholas J
Department of Medicine, Faculty of Medical Science, National University of Laos, Savannakhet, Lao People's Democratic Republic.
Clin Infect Dis. 2003 Oct 15;37(8):1021-8. doi: 10.1086/377734. Epub 2003 Sep 25.
The in vivo efficacies of the Lao People's Democratic Republic (Laos) nationally recommended antimalarial agents--chloroquine and sulfadoxine-pyrimethamine-were assessed in a randomized, comparative trial that involved 100 patients with uncomplicated Plasmodium falciparum malaria who were followed for 42 days after starting treatment. Despite a shorter mean time to fever clearance associated with administration of chloroquine (mean time to clearance, 35.6 h; 95% confidence interval [CI], 26.3-45.0 h), compared with that associated with sulfadoxine-pyrimethamine (61.1 h; 95% CI, 50.9-71.3 h; P<.001), treatment failures were twice as frequent among patients receiving chloroquine therapy than among those receiving sulfadoxine-pyrimethamine therapy (36% vs. 18%; P=.02). Of 23 treatment failures, 10 (43%) were high grade. Treatment failure rates among children (age range, 5-15 years) were 4.9 times higher (95% CI, 2-12) than those among adults (P<.0001). Gametocytemia after antimalarial treatment was associated with receipt of sulfadoxine-pyrimethamine therapy and with treatment failure (P=.009). The efficacy of both chloroquine and sulfadoxine-pyrimethamine in Laos is unsatisfactory.
在一项随机对照试验中，对老挝人民民主共和国（老挝）国家推荐的抗疟药物——氯喹和磺胺多辛-乙胺嘧啶的体内疗效进行了评估。该试验纳入了100例非复杂性恶性疟原虫疟疾患者，在开始治疗后对其进行了42天的随访。尽管与服用磺胺多辛-乙胺嘧啶相比，服用氯喹后发热消退的平均时间较短（消退平均时间：35.6小时；95%置信区间[CI]，26.3 - 45.0小时），而服用磺胺多辛-乙胺嘧啶的为61.1小时；95% CI，50.9 - 71.3小时；P<0.001），但接受氯喹治疗的患者治疗失败的频率是接受磺胺多辛-乙胺嘧啶治疗患者的两倍（36%对18%；P = 0.02）。在23例治疗失败病例中，10例（43%）为重度。儿童（年龄范围5 - 15岁）的治疗失败率比成人高4.9倍（95% CI，2 - 12）（P<0.0001）。抗疟治疗后的配子体血症与接受磺胺多辛-乙胺嘧啶治疗以及治疗失败相关（P = 0.009）。氯喹和磺胺多辛-乙胺嘧啶在老挝的疗效均不令人满意。
