Hong David S, Jacobson Kalen L, Raad Issam I, de Lima Marcos, Anderlini Paolo, Fuller Gregory N, Ippoliti Cindy, Cool Rita M, Leeds Norman E, Narvios Aida, Han Xiang Y, Padula Anthony, Champlin Richard E, Hosing Chitra
Department of Blood and Marrow Transplantation, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
Clin Infect Dis. 2003 Oct 15;37(8):1044-9. doi: 10.1086/378278. Epub 2003 Sep 18.
Most human cases of West Nile virus infection are acquired via bites from an infected mosquito. In some cases, infection may also be transmitted by infected blood products or transplanted organs. There have been recent publications suggesting that chemotherapy and immunosuppression may increase a person's risks of developing central nervous system disease if the person is infected with the West Nile virus. Because patients undergoing hematopoietic stem cell transplantation not only are immunocompromised, but also receive multiple blood products, they are at a particularly high risk for acquiring symptomatic disease if exposed to the West Nile Virus. We describe here 2 patients who underwent hematopoietic transplantation at our institution and subsequently developed fatal West Nile virus infections.
大多数人类西尼罗河病毒感染病例是通过被感染蚊子叮咬而获得的。在某些情况下，感染也可能通过受感染的血液制品或移植器官传播。最近有出版物表明，如果感染了西尼罗河病毒，化疗和免疫抑制可能会增加一个人患中枢神经系统疾病的风险。由于接受造血干细胞移植的患者不仅免疫功能低下，而且会接受多种血液制品，因此如果接触西尼罗河病毒，他们感染症状性疾病的风险特别高。我们在此描述了2例在我们机构接受造血移植并随后发生致命西尼罗河病毒感染的患者。
