Lenz Heinz Josef
Division of Oncology, University of Southern California/Norris Comprehensive Cancer Center, USC Keck School of Medicine, Los Angeles, CA 90033, USA.
Semin Oncol. 2003 Aug;30(4 Suppl 15):47-53. doi: 10.1016/s0093-7754(03)00405-6.
The goal in administering chemotherapeutics is to develop the ability to predict the outcome of therapy in terms of response and toxicity. Technology has been developed to allow tumor profiling with the measurement of protein expression and gene expression levels of markers and even genetic polymorphisms that may predict response to particular chemotherapeutics. The chemotherapeutics for which particular markers have been shown to predict outcome include the fluoropyrimidines and platinums. The next step is to develop clinical trials that will prospectively assess the benefits of profiling a patient's particular tumor, which should translate into an improvement in response and toxicity.
使用化疗药物的目标是培养根据反应和毒性预测治疗结果的能力。现已开发出相关技术，可通过测量标志物的蛋白质表达和基因表达水平，甚至可能预测对特定化疗药物反应的基因多态性来进行肿瘤分析。已证明特定标志物可预测治疗结果的化疗药物包括氟嘧啶和铂类药物。下一步是开展临床试验，前瞻性地评估对患者特定肿瘤进行分析的益处，这有望转化为反应和毒性方面的改善。
