Klarhöfer Markus, Dilharreguy Bixente, van Gelderen Peter, Moonen Chrit T W
Imagerie Moléculaire et Fonctionelle: de la Physiologie à la Thérapie, ERT CNRS/Université Victor Segalen Bordeaux 2, Bordeaux, France.
Magn Reson Med. 2003 Oct;50(4):830-8. doi: 10.1002/mrm.10599.
A 3D sequence for dynamic susceptibility imaging is proposed which combines echo-shifting principles (such as PRESTO), sensitivity encoding (SENSE), and partial-Fourier acquisition. The method uses a moderate SENSE factor of 2 and takes advantage of an alternating partial k-space acquisition in the "slow" phase encode direction allowing an iterative reconstruction using high-resolution phase estimates. Offering an isotropic spatial resolution of 4 x 4 x 4 mm(3), the novel sequence covers the whole brain including parts of the cerebellum in 0.5 sec. Its temporal signal stability is comparable to that of a full-Fourier, full-FOV EPI sequence having the same dynamic scan time but much less brain coverage. Initial functional MRI experiments showed consistent activation in the motor cortex with an average signal change slightly less than that of EPI.
提出了一种用于动态磁化率成像的3D序列，该序列结合了回波移位原理（如PRESTO）、灵敏度编码（SENSE）和部分傅里叶采集。该方法使用2的适度SENSE因子，并在“慢”相位编码方向利用交替的部分k空间采集，允许使用高分辨率相位估计进行迭代重建。这种新颖的序列提供4×4×4 mm³的各向同性空间分辨率，在0.5秒内覆盖整个大脑，包括部分小脑。其时间信号稳定性与具有相同动态扫描时间但脑覆盖范围小得多的全傅里叶、全视野EPI序列相当。最初的功能磁共振成像实验显示运动皮层有一致的激活，平均信号变化略小于EPI。
