Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden.
Magn Reson Med. 2013 Dec;70(6):1507-14. doi: 10.1002/mrm.24594. Epub 2013 Jan 28.
To acquire isotropic high-resolution, signal-to-noise ratio (SNR) efficient, 3D encoded diffusion-weighted MRI data.
Multiple Fourier encoded slabs were combined into one full volume, using a generalized autocalibrating partially parallel acquisitions (GRAPPA) accelerated diffusion-weighted 3D multislab echo planar imaging (EPI) sequence with 2D phase navigation and in-plane motion correction.
Reconstructed data with 1.5-mm(3) nominal resolution is presented and shown under the influence of motion and with variable slab thicknesses. The SNR efficiency between diffusion-weighted 3D multislab EPI and DW 2D ss-EPI is compared. Finally, a 1.3-mm(3) full brain scan with 45 diffusion directions is presented.
Diffusion-weighted 3D multislab EPI has been presented as an alternative sequence for high-resolution and high-SNR full brain coverage diffusion studies. Compared with the gold standard 2D diffusion-weighted single-shot Echo Planar Imaging, the SNR efficiency is significantly higher.
获取各向同性、高分辨率、信噪比（SNR）高效的 3D 编码扩散加权 MRI 数据。
使用广义自校准部分并行采集（GRAPPA）加速的扩散加权 3D 多层面回波平面成像（EPI）序列，结合二维相位导航和平面内运动校正，将多个傅里叶编码层面组合成一个完整的容积。
呈现了具有 1.5mm(3)名义分辨率的重建数据，并展示了在运动影响下和不同层面厚度下的数据。比较了扩散加权 3D 多层面 EPI 与 DW 2D ss-EPI 的 SNR 效率。最后，呈现了一个具有 45 个扩散方向的 1.3mm(3)全脑扫描。
扩散加权 3D 多层面 EPI 已作为一种替代序列，用于高分辨率和高 SNR 全脑覆盖扩散研究。与金标准的 2D 扩散加权单次激发 EPI 相比，其 SNR 效率显著更高。
