高泌乳素血症患者外周血淋巴细胞中淋巴因子激活杀伤细胞（LAK）的正常发育。

Normal development of lymphokine activated killing (LAK) in peripheral blood lymphocytes from hyperprolactinemic patients.

作者信息

Matera L, Ciccarelli E, Muccioli G, Cesano A, Grottoli S, Oberholtzer E, Camanni F

机构信息

Institute of Internal Medicine, University of Turin, Italy.

出版信息

Int J Immunopharmacol. 1992 Oct;14(7):1235-40. doi: 10.1016/0192-0561(92)90059-t.

DOI:10.1016/0192-0561(92)90059-t

PMID:1452408

Abstract

The effect of prolactin on the interleukin 2 (IL2)-driven development of Lymphokine Activated Killing (LAK) by normal PBL and by PBL from hyperprolactinemic patients was investigated. Concentrations of PRL corresponding to the physiological serum levels of the hormone and to the Kd of the PRL receptors on NK cells (6-20 ng/ml, 0.3-1 nM) had no effect on the generation of LAK activity by normal PBL, whereas 100-200 ng/ml were slightly, although significantly, inhibitory. By contrast, PBL from 16 hyperprolactinemic patients developed levels of LAK activity comparable with those generated by PBL from age- and sex-matched normoprolactinemic donors.

摘要

研究了催乳素对正常外周血淋巴细胞（PBL）以及高催乳素血症患者的PBL在白细胞介素2（IL2）驱动下的淋巴因子激活杀伤细胞（LAK）发育的影响。与该激素的生理血清水平以及NK细胞上催乳素受体的解离常数（Kd）相对应的催乳素浓度（6 - 20 ng/ml，0.3 - 1 nM）对正常PBL产生LAK活性没有影响，而100 - 200 ng/ml虽然有显著抑制作用，但抑制作用较弱。相比之下，16例高催乳素血症患者的PBL产生的LAK活性水平与年龄和性别匹配的正常催乳素血症供体的PBL产生的水平相当。