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[巨细胞病毒感染对儿童和青少年结核病病程的影响]

[Impact of cytomegalovirus infection on the course of tuberculosis in children and adolescents].

作者信息

Sirenko I A, Shmat'ko S A, Smelianskaia M V, Peremot S D, Marchenko O Iu, Podoprigora N M

出版信息

Probl Tuberk Bolezn Legk. 2003(8):7-9.

PMID:14524090
Abstract

Sixty-five children and adolescents with respiratory tuberculosis were examined to determine the proportion of cytomegalovirus infection among patients with tuberculosis and its impact on the occurrence and course of different forms of tuberculosis. The number of children and adolescents infected with cytomegalovirus among the patients with respiratory tuberculosis (66.2%) was found to be three times more than that among those not infected with tuberculosis (21.0). The absolute majority (91.3%) of the examinees with the complicated course of a tuberculous process were carriers of cytomegalovirus. They were found to have both antigens and antibodies to cytomegalovirus 9 times more frequently than patients with the smooth course of tuberculosis, which is indicative of the activity of cytomegalovirus infection. The findings suggest that cytomegalovirus infection has an impact on the occurrence and pattern of a tuberculous process.

摘要

对65名患有呼吸道结核的儿童和青少年进行了检查,以确定结核病患者中巨细胞病毒感染的比例及其对不同形式结核病发生和病程的影响。结果发现,呼吸道结核患者中感染巨细胞病毒的儿童和青少年数量(66.2%)是未感染结核病患者(21.0%)的三倍。结核病程复杂的受检者中,绝大多数(91.3%)是巨细胞病毒携带者。与结核病程平稳的患者相比,他们被发现同时具有巨细胞病毒抗原和抗体的频率高出9倍,这表明巨细胞病毒感染具有活性。研究结果表明,巨细胞病毒感染对结核病程的发生和模式有影响。

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