Ding Yan, Zhao Lei, Mei Hong, Zhang Shu-Ling, Huang Zhi-Hua
Department of Gastroenterology and Hepatology, Wuhan Children's Hospital, Wuhan, Hubei Province, People's Republic of China.
Pediatr Hematol Oncol. 2007 Apr-May;24(3):179-88. doi: 10.1080/08880010601166421.
This project explores the specificity of myeloid human cytomegalovirus (HCMV) infection in pathogenesis of idiopathic thrombocytopenic purpura (ITP). Eighty-one subjects with ITP were observed. HCMV early antigen and related myeloid cells in bone marrow, and platelet, HCMV IgM, and IgG in blood were tested. The results presented potent evidence that myeloid HCMV infection is a specific factor in children's ITP: patients of ITP with myeloid HCMV infection had a tendency for exacerbation, refractoriness, and chronic advance. However, HCMV did not affect the quantity of megakaryocyte, which showed the complicated relationships between HCMV and ITP.
本项目探讨人巨细胞病毒（HCMV）髓系感染在特发性血小板减少性紫癜（ITP）发病机制中的特异性。观察了81例ITP患者。检测了骨髓中HCMV早期抗原及相关髓系细胞，以及血液中的血小板、HCMV IgM和IgG。结果提供了有力证据，表明髓系HCMV感染是儿童ITP的一个特异性因素：伴有髓系HCMV感染的ITP患者有病情加重、难治及慢性进展的倾向。然而，HCMV并不影响巨核细胞数量，这表明HCMV与ITP之间存在复杂的关系。
