Zawilska Jolanta B
Zakład Farmakodynamiki Uniwersytetu Medycznego, Zakład Amin Biogennych PAN w Łodzi.
Postepy Hig Med Dosw. 2003;57(3):293-322.
Dopamine (DA) is an important neurotransmitter/neuromodulator that plays various functions within the body. In the central nervous system, DA is involved in the control of locomotion, cognition, emotion, neuroendocrine secretion and function of retinal cells. In the periphery, DA participates in the regulation of homeostasis, vascular tone and hormone secretion. The diverse physiological functions of DA are mediated by at least five distinct membrane bound receptors, i.e. D1 and D5--members of D1 family, and D2, D3, D4--members of D2 family of DA receptors. All DA receptors belong to the superfamily of G-protein-coupled receptors. This survey summarizes current knowledge on the molecular and pharmacological characterization of DA receptors, their role in the regulation of various processes in an organism, and involvement in the therapy of several disorders, in particular in the treatment of Parkinson's disease, schizophrenia, and hypertension.
多巴胺（DA）是一种重要的神经递质/神经调质，在体内发挥多种功能。在中枢神经系统中，DA参与运动控制、认知、情绪、神经内分泌分泌以及视网膜细胞的功能。在周围组织中，DA参与体内稳态、血管张力和激素分泌的调节。DA的多种生理功能至少由五种不同的膜结合受体介导，即D1和D5（D1家族成员）以及D2、D3、D4（DA受体D2家族成员）。所有DA受体都属于G蛋白偶联受体超家族。本综述总结了关于DA受体的分子和药理学特性、它们在生物体各种过程调节中的作用以及参与多种疾病治疗，特别是帕金森病、精神分裂症和高血压治疗的当前知识。
