Howell Susan, Hoffman Kathleen, Bartel Lyle, Schwandt Melanie, Morris Joanne, Fritz Jo
Primate Foundation of Arizona, PO Box 20027, Mesa, Arizona 85277-0027, USA.
Comp Med. 2003 Aug;53(4):413-23.
In the study reported here, reference intervals for hematologic and serum clinical chemistry variables in the chimpanzee (Pan troglodytes) were developed and characterized. Data were collected longitudinally across a 10-year period for 86 subjects at the Primate Foundation of Arizona (PFA). Variables included nine standard hematologic and 25 standard serum clinical chemistry values. An analysis of variance (ANOVA) was used to test for main effects by age and sex. In addition, PFA mean and range values were compared with those published for humans and six other chimpanzee colonies. The ANOVA results suggest an age effect on hematologic (mean corpuscular hemoglobin, mean corpuscular volume, neutrophils) and serum clinical chemical (creatinine, total protein, globulin, tryglycerides, direct bilirubin, iron, (gamma-glutamyltransferase, alanine transaminase, creatine kinase) values. In addition, sex had a main effect on several variables (red blood cells, hemoglobin concentration, hematocrit, uric acid and sodium concentrations, and aspartate transminase and creatine kinase activities); values for males were greater than those for females. Further, human and chimpanzee mean and range values often were indistinguishable from one another. However, changes in human and chimpanzee values associated with age differ and suggest that hematologic and serum clinical chemistry values may be differentially affected by physical and sexual maturation in humans and chimpanzees.
在本报告的研究中，制定并描述了黑猩猩（Pan troglodytes）血液学和血清临床化学变量的参考区间。在10年期间，对亚利桑那州灵长类动物基金会（PFA）的86只受试动物进行了纵向数据收集。变量包括9项标准血液学指标和25项标准血清临床化学指标。采用方差分析（ANOVA）来检验年龄和性别的主效应。此外，将PFA的均值和范围值与已发表的人类及其他六个黑猩猩群体的值进行了比较。方差分析结果表明，年龄对血液学指标（平均红细胞血红蛋白含量、平均红细胞体积体积、中性粒细胞）和血清临床化学指标（肌酐、总蛋白、球蛋白、甘油三酯、直接胆红素、铁、γ-谷氨酰转移酶、丙氨酸转氨酶、肌酸激酶）有影响。此外，性别对几个变量有主效应（红细胞、血红蛋白浓度、血细胞比容、尿酸和钠浓度以及天冬氨酸转氨酶和肌酸激酶活性）；雄性的值高于雌性。此外，人类和黑猩猩的均值及范围值常常难以区分。然而，人类和黑猩猩与年龄相关的值的变化有所不同，这表明血液学和血清临床化学值在人类和黑猩猩中可能受到身体和性成熟的不同影响。
