Hainsey B M, Hubbard G B, Leland M M, Brasky K M
Southwest Foundation for Biomedical Research, San Antonio, TX 78228-0147.
Lab Anim Sci. 1993 Jun;43(3):236-43.
Improved equipment and advanced progressive techniques by scientists using baboons and chimpanzees in biomedical research have resulted in improved clinical laboratory data. The use of state-of-the-art clinical laboratory instruments, methodologies with improved accuracy, and an increased variety of individual tests routinely requested and performed has necessitated the comparison of current data with prior data produced in our laboratory and with those values reported in the literature. In addition to an expanded hematologic profile, including red blood cell distribution width and mean platelet volume, and a more comprehensive chemical profile of 28 individual tests, additional data collected included values for coagulation profiles, arterial blood gases, serum protein electrophoresis, and urine osmolalities. Samples for evaluation were obtained from clinically normal sedated adult baboons (Papio species) and chimpanzees (Pan troglodytes) and processed conventionally according to Good Laboratory Practice Act standards. Arithmetic means were calculated, values of 3 standard deviations or greater were eliminated, and means were recalculated to include 2 standard deviations. All data correlated well with prior in-house values, and no remarkable differences from established data were detected, thus indicating the reliability of past and present data. Data compared favorably with normal clinical values established for humans.
科学家在生物医学研究中使用狒狒和黑猩猩改进了设备并采用了先进的渐进技术，从而使临床实验室数据得到了改善。使用最先进的临床实验室仪器、准确性更高的方法以及常规要求和执行的个体检测种类增加，这就需要将当前数据与我们实验室之前产生的数据以及文献中报道的那些值进行比较。除了扩展的血液学指标，包括红细胞分布宽度和平均血小板体积，以及涵盖28项个体检测的更全面的化学指标外，收集的其他数据还包括凝血指标、动脉血气、血清蛋白电泳和尿渗透压的值。用于评估的样本取自临床正常的成年镇静狒狒（狒狒属物种）和黑猩猩（黑猩猩），并按照良好实验室规范标准进行常规处理。计算算术平均值，剔除3个或更大标准差的值，然后重新计算平均值以包括2个标准差。所有数据与之前的内部值相关性良好，未检测到与既定数据有显著差异，因此表明过去和现在数据的可靠性。这些数据与为人类确定的正常临床值相比情况良好。
