Kim O, YI S J
USDA-ARS, ADRU, 319 Bustad, WSU, Pullman, WA 99164, USA.
Acta Virol. 2003;47(2):91-5.
Although many viruses can induce apoptosis in infected cells, large DNA viruses, such as poxviruses, herpesviruses and adenoviruses, usually exhibit the ability to suppress the induction of apoptosis in the infected cells. We investigated the ability of Human herpesvirus 8 (HHV-8) to protect cells from apoptosis induced by the virus. HHV-8 has been shown to harbor genes with anti-apoptotic capacity. However, we demonstrate here that a lytic replication of HHV-8 resulted in induction of apoptosis using different techniques to detect apoptosis. Therefore, despite the presence of anti-apoptotic genes in its genome, HHV-8 could complete its cycle of productive infection while inducing apoptosis in infected cells. This finding might have implications for the pathobiology of HHV-8 and other gamma herpesviruses in vivo.
尽管许多病毒可在感染细胞中诱导细胞凋亡，但大型DNA病毒，如痘病毒、疱疹病毒和腺病毒，通常表现出抑制感染细胞中细胞凋亡诱导的能力。我们研究了人类疱疹病毒8型（HHV-8）保护细胞免受该病毒诱导的细胞凋亡的能力。HHV-8已被证明含有具有抗凋亡能力的基因。然而，我们在此证明，HHV-8的裂解复制通过使用不同技术检测细胞凋亡而导致细胞凋亡的诱导。因此，尽管其基因组中存在抗凋亡基因，但HHV-8仍可在感染细胞中诱导细胞凋亡的同时完成其生产性感染周期。这一发现可能对HHV-8和其他γ疱疹病毒在体内的病理生物学具有重要意义。
