Longman L P, Marsh P D, Martin M V
Department of Clinical Dental Sciences, University of Liverpool, UK.
J Antimicrob Chemother. 1992 Sep;30(3):349-52. doi: 10.1093/jac/30.3.349.
The ability of three amoxycillin-resistant strains of Streptococcus sanguis 254, 24 and 297 (MIC 40 mg/L) to cause infective endocarditis (IE) in the rabbit was investigated. These strains all produced infection in the rabbit, as did an antibiotic sensitive control strain NCTC 7864. Prophylactic amoxycillin (400 mg/kg body weight) administered one hour before bacterial challenge prevented 80% of the animals developing IE irrespective of the challenging strain. It is concluded that amoxycillin-resistant strains of S. sanguis can cause IE and that amoxycillin prophylaxis can still be effective against these bacteria.
研究了血链球菌254、24和297这三株对阿莫西林耐药的菌株（最低抑菌浓度为40mg/L）在兔体内引起感染性心内膜炎（IE）的能力。这些菌株在兔体内均引发了感染，抗生素敏感对照菌株NCTC 7864也是如此。在细菌攻击前一小时给予预防性阿莫西林（400mg/kg体重）可使80%的动物预防IE的发生，无论攻击菌株是什么。结论是血链球菌的阿莫西林耐药菌株可引起IE，并且阿莫西林预防对这些细菌仍然有效。
