Kalra O P, Aggarwal H K, Mahajan S K, Seth R K
University College of Medical Sciences, Shahdara, Delhi.
J Assoc Physicians India. 1992 Apr;40(4):233-6.
The effect of sodium nitroprusside (SNP), a vasodilator drug, and chlorpromazine (CPZ), a surface active drug, on the efficacy of peritoneal dialysis was studied in 25 patients with acute or acute on chronic renal failure in a double blind fashion. Each drug was added to the dialysate during different sets of cycles. In each patient, six clearance periods of 3 cycles each were studied and peritoneal clearances of creatinine and urea and ultrafiltration rates were measured during each clearance period. SNP increased the peritoneal clearance of creatinine and urea by 28.8 percent each (p < 0.001) while CPZ increased the peritoneal creatinine and urea clearance by 17.7 and 26.0 percent respectively (p < 0.001 each). Both drugs significantly increased the ultrafiltration rates (p < 0.001). SNP was found to be superior to CPZ and had prolonged effect even after cessation of administration.
以双盲方式，对25例急性或慢性肾衰竭急性发作患者，研究了血管扩张剂硝普钠（SNP）和表面活性药物氯丙嗪（CPZ）对腹膜透析疗效的影响。在不同的透析周期组中，将每种药物添加到透析液中。对每位患者，研究了6个清除期，每个清除期为3个周期，并在每个清除期测量肌酐和尿素的腹膜清除率以及超滤率。SNP使肌酐和尿素的腹膜清除率各提高了28.8%（p<0.001），而CPZ使腹膜肌酐和尿素清除率分别提高了17.7%和26.0%（均p<0.001）。两种药物均显著提高了超滤率（p<0.001）。发现SNP优于CPZ，甚至在停药后仍有延长的效果。
