Finkelstein F O, Yap P, Kliger A S
Yale J Biol Med. 1980 Mar-Apr;53(2):127-32.
We have studied the effect of intraperitoneal nitroprusside on small (urea) and middle (vitamin B12) molecule dialysis clearances in patients maintained on chronic peritoneal dialysis. Clearances were measured in six patients during the addition of 6 mg of nitroprusside to three and seven consecutive, hourly two-liter exchanges during the course of a routine dialysis treatment. Results indicate that clearances of urea and B12 both increased about 35 percent with the addition of the vasodilator for three exchanges. Clearances immediately returned to baseline values when administration of the vasodilator was discontinued. Addition of the drug to seven consecutive exchanges resulted in a sustained 35 percent increment in clearances. We conclude that addition of 6 mg of nitroprusside to peritoneal dialysis solution can result in a significant increment in both small and middle molecule clearances. Maintenance of the higher clearances requires sustained administration of the drug, which can be tolerated for at least six exchanges with no adverse side effects.
我们研究了腹腔内注射硝普钠对接受慢性腹膜透析患者的小分子（尿素）和中分子（维生素B12）透析清除率的影响。在常规透析治疗过程中，对6名患者进行了测量，即在连续3次和7次每小时2升的交换中添加6毫克硝普钠。结果表明，添加血管扩张剂进行3次交换后，尿素和维生素B12的清除率均提高了约35%。停止使用血管扩张剂后，清除率立即恢复到基线值。连续7次交换添加该药物导致清除率持续提高35%。我们得出结论，向腹膜透析液中添加6毫克硝普钠可导致小分子和中分子清除率显著提高。维持较高的清除率需要持续给药，至少进行6次交换时可耐受且无不良副作用。
