Eisenberg Eli, Levanon Erez Y
Compugen Ltd., 72 Pinchas Rosen Street, Tel Aviv 69512, Israel.
Phys Rev Lett. 2003 Sep 26;91(13):138701. doi: 10.1103/PhysRevLett.91.138701.
The Saccharomyces cerevisiae protein-protein interaction map, as well as many natural and man-made networks, shares the scale-free topology. The preferential attachment model was suggested as a generic network evolution model that yields this universal topology. However, it is not clear that the model assumptions hold for the protein interaction network. Using a cross-genome comparison, we show that (a) the older a protein, the better connected it is, and (b) the number of interactions a protein gains during its evolution is proportional to its connectivity. Therefore, preferential attachment governs the protein network evolution. Evolutionary mechanisms leading to such preference and some implications are discussed.
酿酒酵母的蛋白质-蛋白质相互作用图谱，以及许多自然和人工网络，都具有无标度拓扑结构。优先连接模型被认为是产生这种通用拓扑结构的一般网络进化模型。然而，尚不清楚该模型假设是否适用于蛋白质相互作用网络。通过跨基因组比较，我们发现：（a）一种蛋白质存在的时间越长，其连接性就越好；（b）一种蛋白质在其进化过程中获得的相互作用数量与其连接性成正比。因此，优先连接决定了蛋白质网络的进化。我们还讨论了导致这种偏好的进化机制及其一些影响。
