Wuchty S, Oltvai Z N, Barabási A-L
Department of Physics, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Nat Genet. 2003 Oct;35(2):176-9. doi: 10.1038/ng1242. Epub 2003 Sep 14.
Understanding why some cellular components are conserved across species but others evolve rapidly is a key question of modern biology. Here we show that in Saccharomyces cerevisiae, proteins organized in cohesive patterns of interactions are conserved to a substantially higher degree than those that do not participate in such motifs. We find that the conservation of proteins in distinct topological motifs correlates with the interconnectedness and function of that motif and also depends on the structure of the overall interactome topology. These findings indicate that motifs may represent evolutionary conserved topological units of cellular networks molded in accordance with the specific biological function in which they participate.
理解为何某些细胞成分在物种间保守而其他成分快速进化是现代生物学的一个关键问题。在此我们表明，在酿酒酵母中，以凝聚性相互作用模式组织的蛋白质比那些不参与此类基序的蛋白质保守程度要高得多。我们发现，不同拓扑基序中蛋白质的保守性与该基序的相互连接性和功能相关，并且还取决于整体相互作用组拓扑结构。这些发现表明，基序可能代表了根据它们所参与的特定生物学功能塑造的细胞网络进化保守拓扑单元。
