Gupta V K, Mukherjee S, Dutta S K, Mukherjee P
Department of Medicine, Medical College & Hospitals, Calcutta.
J Assoc Physicians India. 1992 Jun;40(6):387-9.
Activity of adenosine deaminase (ADA) in serum and peritoneal fluid was studied prospectively in 24 aetiologically proved cases of ascites and 10 age-matched controls. Patients were divided into 3 groups according to causes of ascites, viz. malignant ascites (11), tubercular peritonitis (7) and cirrhosis of liver (6). Serum ADA values and peritoneal: serum ADA ratio did not show any consistent pattern in any group. But in patients with tubercular peritonitis ADA activity in ascitic fluid was significantly higher (P < .001) than in the other groups. An ascitic ADA level of 30 units/L had a sensitivity of 100% and specificity of 94.1% for tubercular peritonitis. These findings suggest that the ascitic fluid ADA activity is useful for the diagnosis of tubercular peritonitis; this method is simple and least invasive.
对24例病因明确的腹水患者和10例年龄匹配的对照者的血清及腹腔积液中的腺苷脱氨酶（ADA）活性进行了前瞻性研究。根据腹水病因将患者分为3组，即恶性腹水（11例）、结核性腹膜炎（7例）和肝硬化（6例）。血清ADA值及腹腔积液与血清ADA比值在任何一组中均未显示出一致的模式。但结核性腹膜炎患者腹腔积液中的ADA活性显著高于其他组（P <.001）。腹腔积液ADA水平为30单位/L时，对结核性腹膜炎的敏感性为100%，特异性为94.1%。这些结果表明，腹腔积液ADA活性对结核性腹膜炎的诊断有用；该方法简单且侵入性最小。
