Northam E, Bowden S, Anderson V, Court J
Department of Psychology, Royal Children's Hospital, Melbourne, Victoria, Australia.
J Clin Exp Neuropsychol. 1992 Nov;14(6):884-900. doi: 10.1080/01688639208402542.
Investigated the relationship between disease variables, neuropsychological performance, and psychosocial status in adolescents with Insulin Dependent Diabetes Mellitus (IDDM). The study group consisted of 85 adolescents, aged 14 to 16.5 years who had been diabetic for longer than 12 months. Parameters of both recent and long-term metabolic control were determined, including diabetic incidents such as severe hypoglycemia or ketoacidosis. The mothers completed standardised measures of adolescent adjustment, and the adolescents provided self-reports of psychosocial status. Neuropsychological functioning was evaluated with standardised tests of verbal and nonverbal intelligence, memory and new learning, visuo-graphic skills, mental flexibility, and problem-solving ability. Using retrospective accounts of disease history, there was no relationship between neuropsychological functioning and variables such as age of onset, chronic poor control, or major metabolic crises. The findings emphasise the need for a long-term, prospective study of a cohort of diabetic children from the time of diagnosis to clarify causal relationships, if any, between illness variables, neuropsychological performance, and psychosocial factors.
研究了胰岛素依赖型糖尿病（IDDM）青少年患者的疾病变量、神经心理表现和社会心理状况之间的关系。研究组由85名年龄在14至16.5岁之间、患糖尿病超过12个月的青少年组成。测定了近期和长期代谢控制的参数，包括严重低血糖或酮症酸中毒等糖尿病事件。母亲们完成了青少年适应情况的标准化测量，青少年提供了社会心理状况的自我报告。通过语言和非语言智力、记忆与新学习、视觉图形技能、心理灵活性和解决问题能力的标准化测试对神经心理功能进行了评估。利用疾病史的回顾性记录，神经心理功能与发病年龄、长期控制不佳或重大代谢危机等变量之间没有关系。研究结果强调，需要对一组糖尿病儿童从诊断开始进行长期的前瞻性研究，以阐明疾病变量、神经心理表现和社会心理因素之间是否存在因果关系。
