利用植物生产重组药用蛋白。

The production of recombinant pharmaceutical proteins in plants.

作者信息

Ma Julian K-C, Drake Pascal M W, Christou Paul

机构信息

Department of Infectious Diseases, St. George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK.

出版信息

Nat Rev Genet. 2003 Oct;4(10):794-805. doi: 10.1038/nrg1177.

DOI:10.1038/nrg1177

PMID:14526375

Abstract

Imagine a world in which any protein, either naturally occurring or designed by man, could be produced safely, inexpensively and in almost unlimited quantities using only simple nutrients, water and sunlight. This could one day become reality as we learn to harness the power of plants for the production of recombinant proteins on an agricultural scale. Molecular farming in plants has already proven to be a successful way of producing a range of technical proteins. The first plant-derived recombinant pharmaceutical proteins are now approaching commercial approval, and many more are expected to follow.

摘要

想象这样一个世界

任何蛋白质，无论是天然存在的还是人类设计的，都可以仅使用简单的养分、水和阳光安全、廉价且几乎不受限制地大量生产。随着我们学会利用植物的力量在农业规模上生产重组蛋白，这有朝一日可能会成为现实。植物分子农业已被证明是生产一系列技术蛋白的成功方法。首批植物源重组药物蛋白目前正接近商业批准阶段，预计随后还会有更多产品获批。