Wang Jun, Feng Jianfei, Zhang Li, Hu Yu, Luan Bin, Yue Weihai, Wang Hong, Zhu Shaoxian, Xu Yumei
Department of Hematology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
J Huazhong Univ Sci Technolog Med Sci. 2003;23(3):239-41. doi: 10.1007/BF02829502.
To investigate the distribution of variant genotypes of Fc gamma receptor IIIa (Fc gamma R IIIa) in healthy Chinese population of Zhengzhou city, genomic DNA was extracted from peripheral blood of healthy donators. The genotypes of Fc gamma R IIIa-158 were determined by nested polymerase chain reaction (PCR) in 137 healthy people in Zhengzhou city. The results showed that frequencies of variant genotypes FF, VV and VF were 42.3%, 48.9% and 8.8% respectively. The distribution of Fc gamma R IIIa-158 in healthy Chinese population of Zhengzhou city was polymorphic and different from that of African Americans (AA) and Caucasian Americans (CA).
为研究郑州市健康汉族人群中Fcγ受体Ⅲa（FcγRⅢa）变异基因型的分布情况，从健康献血者外周血中提取基因组DNA。采用巢式聚合酶链反应（PCR）法对郑州市137名健康人进行FcγRⅢa-158基因型检测。结果显示，变异基因型FF、VV和VF的频率分别为42.3%、48.9%和8.8%。郑州市健康汉族人群中FcγRⅢa-158的分布具有多态性，与非裔美国人和高加索裔美国人不同。
