一些含锗（IV）和锡（IV）氯化物配合物的硝酮衍生物的制备及抗菌评价
Preparation and antibacterial evaluation of some nitrone derivatives with Ge(IV) and Sn(IV) chloride complexes.
作者信息
Khallow K I, Sulayman K D, al-Ubaidi E A
机构信息
Dept. of Chemistry, College of Education, University of Mosul, Iraq.
出版信息
Boll Chim Farm. 2003 Jun;142(5):223-5.
New complexes of the general formula MCl3.L where L1 = [N-p-chlorophenyl)-alpha-(2-xanthatonaphthol)nitrone, L2 = [N-(p-anisole)-alpha-(2-xanthatonaphthol)nitrone]; M = Ge(IV) and Sn(IV) have been synthesized and characterized by elemental analyses, i.r. and molar conductances. The antibacterial activities of these ligands and their complexes have been studied against six species of bacteria in vitro at concentration ranging from 1-10 micrograms/ml. No activity were observed for the both ligands while a remarkable activities were exhibited by some complexes of both ions Ge(IV) and Sn(IV) against S. aureus, B. subtilis and P. mirabilis even more than the effect of antibacterial used in this study.
通式为MCl3.L的新配合物已被合成并通过元素分析、红外光谱和摩尔电导率进行了表征，其中L1 = [N - 对氯苯基)-α-(2 - 呫吨酮萘酚)硝酮，L2 = [N -(对茴香醚)-α-(2 - 呫吨酮萘酚)硝酮]；M = Ge(IV) 和Sn(IV)。这些配体及其配合物的抗菌活性已在体外针对六种细菌进行了研究，浓度范围为1 - 10微克/毫升。两种配体均未观察到活性，而Ge(IV)和Sn(IV)离子的一些配合物对金黄色葡萄球菌、枯草芽孢杆菌和奇异变形杆菌表现出显著活性，甚至超过了本研究中使用的抗菌剂的效果。
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