Kumar Kodagahally R Ravi, Mallesha Honnaiah, Rangappa Kanchugarakoppal S
Department of Studies in Chemistry, University of Mysore, Manasagangotri, India.
Arch Pharm (Weinheim). 2003 Jun;336(3):159-64. doi: 10.1002/ardp.200390015.
The synthesis of some biologically interesting isoxazolidine derivatives has been accomplished by the cycloaddition reaction of C-(4-biphenyl)-N-(3-methylphenyl) nitrone and C-(4-biphenyl)-N-(3-chlorophenyl) nitrone to monosubstituted alkenes. The compounds were screened for their antibacterial and antifungal activities. Among the tested compounds 3a (ii), 3a (vii), 3a (viii), 3b (iv), 3b (vii), and 3b (viii) showed significant antifungal activity comparable with that of the standard drug Nystatin against Botrydiplodia theobromae.
通过C-（4-联苯基）-N-（3-甲基苯基）硝酮和C-（4-联苯基）-N-（3-氯苯基）硝酮与单取代烯烃的环加成反应，完成了一些具有生物学意义的异恶唑烷衍生物的合成。对这些化合物进行了抗菌和抗真菌活性筛选。在测试的化合物中，3a（ii）、3a（vii）、3a（viii）、3b（iv）、3b（vii）和3b（viii）表现出与标准药物制霉菌素相当的显著抗真菌活性，对可可毛色二孢菌有效。
