在239Pu通过暴露于硝酸的受伤皮肤渗透的情况下成功进行二乙三胺五乙酸（DTPA）治疗。

Successful DTPA therapy in the case of 239Pu penetration via injured skin exposed to nitric acid.

作者信息

Khokhryakov V F, Belyaev A P, Kudryavtseva T I, Schadilov A E, Moroz G S, Shalaginov V A

机构信息

Southern Ural Biophysics Institute, Ozyorsk Road, 19, Ozyorsk Chelyabinsk Region 456780, Russia.

出版信息

Radiat Prot Dosimetry. 2003;105(1-4):499-502. doi: 10.1093/oxfordjournals.rpd.a006291.

DOI:10.1093/oxfordjournals.rpd.a006291

PMID:14527017

Abstract

This paper presents results of the radiological study and DTPA therapy for a worker exposed to a plutonium nitrate solution. Plutonium levels were measured in excreta, blood, plasma and wound for several weeks. Plutonium renal clearance ranged from 110-190 ml min(-1) to 3-4 ml min(-1) at different stages of chelation therapy. Plutonium absorption into blood from the injured skin amounted to 4.3%. As a result of intensive therapy, 96% of absorbed plutonium was successfully excreted.

摘要

本文介绍了对一名接触硝酸钚溶液的工人进行放射学研究和二乙三胺五乙酸（DTPA）治疗的结果。数周内对排泄物、血液、血浆和伤口中的钚含量进行了测量。在螯合治疗的不同阶段，钚的肾脏清除率范围为110 - 190毫升/分钟至3 - 4毫升/分钟。钚从受伤皮肤吸收进入血液的量为4.3%。经过强化治疗，96%的吸收钚被成功排出。