3,4,3-LI(1,2-HOPO)对肌肉注射MOX高燃颗粒的大鼠体内钚、镅和铀促排的效果

Efficacy of 3,4,3-LI(1,2-HOPO) for decorporation of Pu, Am and U from rats injected intramuscularly with high-fired particles of MOX.

作者信息

Paquet F, Chazel V, Houpert P, Guilmette R, Muggenburg B

机构信息

Institut de Radioprotection et de Sûreté Nucléaire, Département de Protection de la Santé de l'Homme et de Dosimétrie, Laboratoire d'Etudes Appliquées de Radiotoxicologie, Cedex, France.

出版信息

Radiat Prot Dosimetry. 2003;105(1-4):521-5. doi: 10.1093/oxfordjournals.rpd.a006296.

DOI:10.1093/oxfordjournals.rpd.a006296

PMID:14535232

Abstract

This study aimed to assess the efficacy of 3,4,3-LI(1,2-HOPO) for reducing uranium, plutonium and americium in rats after intramuscular injection of (U-Pu)O2 particles (MOX). Sixteen rats were contaminated by intramuscular injection of a 1 mg MOX suspension and then treated daily for 7 d with LIHOPO (30 or 200 micromol kg(-1)) or DTPA (30 micromol kg(-1)). LIHOPO was inefficient for removing Pu, Am and U from the wound site. However, it reduced Pu retention in carcass and liver by factors of 2 and 6 respectively, and Am retention in carcass and liver by factors of 10 and 30. In contrast, the effect of LIHOPO on U was to decrease the retention in kidneys by a factor of 75. These results confirm that LIHOPO is a good candidate for use after contamination with MOX, in combination with localised wound lavage or surgical treatment aimed at removing most of the contaminant at the wound site.

摘要

本研究旨在评估肌肉注射（U-Pu）O2颗粒（混合氧化物燃料，MOX）后，3,4,3-LI(1,2-HOPO)对降低大鼠体内铀、钚和镅含量的效果。16只大鼠通过肌肉注射1mg MOX悬浮液受到污染，然后每天用LIHOPO（30或200微摩尔/千克）或二乙三胺五乙酸（DTPA，30微摩尔/千克）治疗7天。LIHOPO在清除伤口部位的钚、镅和铀方面效率不高。然而，它分别使尸体和肝脏中的钚保留量降低了2倍和6倍，使尸体和肝脏中的镅保留量降低了10倍和30倍。相比之下，LIHOPO对铀的作用是使肾脏中的保留量降低了75倍。这些结果证实，LIHOPO是MOX污染后与局部伤口冲洗或旨在清除伤口部位大部分污染物的手术治疗联合使用的良好候选药物。