具有半胱氨酰白三烯受体2拮抗活性的3-乙酰乙酰氨基苯并[b]呋喃衍生物的制备
Preparation of 3-acetoacetylaminobenzo[b]furan derivatives with cysteinyl leukotriene receptor 2 antagonistic activity.
作者信息
Tsuji Eriko, Ando Kumiko, Kunitomo Jun-ichi, Yamashita Masayuki, Ohta Shunsaku, Kohno Shigekatsu, Ohishi Yoshitaka
机构信息
School of Pharmaceutical Sciences, Mukogawa-Women's University, 11-68 Koshien Kyuban-cho, Nishinomiya 663-8179, Japan.
出版信息
Org Biomol Chem. 2003 Sep 21;1(18):3139-41. doi: 10.1039/b307468d.
Novel 3-acetoacetylaminobenzo[b]furan derivatives with a modified triene system at the 3-position were prepared through acylation of the 3-aminobenzo[b]furans with 5-methylisoxazole-4-carboxylic acid chloride followed by basic cleavage of the isoxazole ring and several of these compounds showed moderate cysteinyl leukotriene receptor 2 antagonistic activity.
通过用5-甲基异恶唑-4-羧酸氯对3-氨基苯并[b]呋喃进行酰化反应，然后对异恶唑环进行碱性裂解，制备了在3位具有修饰三烯系统的新型3-乙酰乙酰氨基苯并[b]呋喃衍生物，其中几种化合物表现出中等程度的半胱氨酰白三烯受体2拮抗活性。
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