Marincola Francesco M
Immunogenetics Section, Clinical Center, Department of Transfusion Medicine, NIH, Bethesda MD, 20892, USA.
J Transl Med. 2003 Jul 24;1(1):1. doi: 10.1186/1479-5876-1-1.
The purpose of translational research is to test, in humans, novel therapeutic strategies developed through experimentation. Translational research should be regarded as a two-way road: Bench to Bedside and Bedside to Bench. However, Bedside to Bench efforts have regrettably been limited because the scientific aspects are poorly understood by full time clinicians and the difficulty of dealing with humans poorly appreciated by basic scientists. Translational research would be most useful to the scientific community at large if journals would foster specific interest for the publication of ex vivo human observation. The review process for such work should be assigned to clinical scientists competent not only in the intricacies of molecular or cell biology but also intimate with the reality of Internal Review Boards, ethics committees, Governmental Regulatory Agencies and most importantly the humane aspects of dealing with sick individuals and their families. This approach may focus both basic and clinical scientists and those struggling to fill the gap between them on the effective treatment of diseases affecting women, men and children making translational research more than an interesting concept.
转化研究的目的是在人体中测试通过实验开发的新型治疗策略。转化研究应被视为一条双向道路：从 bench 到 bedside 以及从 bedside 到 bench。然而，遗憾的是，从 bedside 到 bench 的努力一直有限，因为全职临床医生对科学方面了解不足，而基础科学家对涉及人体研究的困难认识不够。如果期刊能激发对发表离体人体观察结果的特别兴趣，转化研究将对整个科学界最为有用。此类工作的评审过程应交给不仅精通分子或细胞生物学复杂性，而且熟悉内部审查委员会、伦理委员会、政府监管机构实际情况的临床科学家，最重要的是，要熟悉与患病个体及其家人打交道的人文方面。这种方法可能会使基础科学家和临床科学家以及那些努力填补他们之间差距的人都专注于有效治疗影响妇女、男子和儿童的疾病，从而使转化研究不仅仅是一个有趣的概念。
