Gaspary João Francisco Pollo, Lopes Luis Felipe Dias, Camara Antonio Geraldo
Institute AuBento - Center for Education, Clinical Practice, and Research in Orthomolecular and Integrative Medicine, Santa Maria, Brazil.
Center for Social and Human Sciences, Postgraduate Program in Administration, Federal University of Santa Maria, Santa Maria, Brazil.
Front Med (Lausanne). 2025 May 20;12:1552904. doi: 10.3389/fmed.2025.1552904. eCollection 2025.
The health industry plays a crucial role in improving the quality of life for individuals, continuously driving innovations in health service delivery. Translational research fosters intimate collaboration between scientists and medical professionals. A major obstacle to effective evidence-based treatments is drug adherence, prompting the search for innovative procedures to enhance drug delivery methods.
This study aimed to assess the impact of innovative drug delivery systems (DDS) based on physical stimuli on medication adherence among patients undergoing long-term treatments. The ultimate goal was to establish a framework-based approach to assist in clinical decision-making, enhancing drug absorption efficiency.
Two systematic literature reviews (SLRs) was conducted across multiple databases, including PubMed, Scopus, and Web of Science, focusing on DDS activated by physical and biological stimuli. The research process was structured through the Work Breakdown Structure (WBS) methodology, dividing it into five interconnected Work Packages (WPs). Each WP explored specific aspects of the relationship between DDS and the human body.
The synthesis led to the development of the Triangle Decision-Making Model, a theoretical framework that prioritizes physiological balance to optimize drug delivery. The study underscores the importance of reducing insulin and cortisol levels to minimize inflammation and glycation, promoting an ideal state for drug absorption. The findings highlight the significance of using physical stimuli, such as hyperthermia, ultrasound-triggered drug delivery, and photodynamic therapy, to enhance drug bioavailability and target specificity.
This research proposes a novel therapeutic intervention, grounded in systematic reviews and focused on improving drug delivery via physical stimuli. Using an open innovation approach, the triangular clinical decision model integrates personalized medicine and nutraceuticals, addressing epigenetics and nutrition's role in medication response. This framework aims to enhance drug absorption, metabolism, and targeted therapies, advancing treatment outcomes. Future studies should refine this model to promote homeostasis and validate its effectiveness across healthcare settings.
健康产业在改善个人生活质量方面发挥着关键作用，不断推动健康服务提供方面的创新。转化研究促进了科学家与医学专业人员之间的密切合作。有效循证治疗的一个主要障碍是药物依从性，这促使人们寻找创新方法来改进药物递送方式。
本研究旨在评估基于物理刺激的创新药物递送系统（DDS）对长期治疗患者药物依从性的影响。最终目标是建立一种基于框架的方法来辅助临床决策，提高药物吸收效率。
在多个数据库（包括PubMed、Scopus和Web of Science）中进行了两项系统文献综述（SLR），重点关注由物理和生物刺激激活的DDS。研究过程通过工作分解结构（WBS）方法进行构建，将其分为五个相互关联的工作包（WP）。每个WP探索了DDS与人体之间关系的特定方面。
综合研究成果形成了三角决策模型，这是一个优先考虑生理平衡以优化药物递送的理论框架。该研究强调了降低胰岛素和皮质醇水平以尽量减少炎症和糖化的重要性，从而促进药物吸收的理想状态。研究结果突出了使用物理刺激（如热疗、超声触发药物递送和光动力疗法）来提高药物生物利用度和靶向特异性的重要性。
本研究提出了一种新颖的治疗干预措施，基于系统综述，专注于通过物理刺激改善药物递送。采用开放式创新方法，三角临床决策模型整合了个性化医疗和营养保健品，探讨了表观遗传学和营养在药物反应中的作用。该框架旨在提高药物吸收、代谢和靶向治疗效果，改善治疗结果。未来的研究应完善该模型以促进体内平衡，并在不同医疗环境中验证其有效性。
