Benjamin B, Annobil S H, Khan M R
Department of Child Health, College of Medicine, King Saud University, Abha, Saudi Arabia.
J Pediatr Orthop. 1992 Nov-Dec;12(6):801-5. doi: 10.1097/01241398-199211000-00019.
Fifty-seven (36%) of a cohort of 157 children with brucellosis from Saudi Arabia had arthritis. Most gave a history of contact with farm animals or drinking unpasteurized milk. Associated features included pyrexia, arthralgia, hepatosplenomegaly, and lymphadenopathy. A subacute presentation with peripheral oligoarthritis predominantly affecting hips or knees was common. Specific chemotherapy resulted in rapid defervescence followed by slower resolution of the arthritis. Children with osteoarticular brucellosis had a higher relapse rate and a longer hospital stay. Supervised combination chemotherapy for at least 6 weeks was effective in preventing relapse. A brucellar etiology should be considered in any child from an endemic area who has osteoarticular manifestations.
来自沙特阿拉伯的157名布鲁氏菌病患儿队列中，57名（36%）有关节炎。大多数患儿有接触农场动物或饮用未杀菌牛奶的病史。相关特征包括发热、关节痛、肝脾肿大和淋巴结病。以周围寡关节炎为主、主要累及髋部或膝部的亚急性表现很常见。特异性化疗导致迅速退热，随后关节炎缓解较慢。骨关节炎型布鲁氏菌病患儿的复发率较高，住院时间较长。至少6周的监督性联合化疗对预防复发有效。来自流行地区且有骨关节炎表现的任何儿童都应考虑布鲁氏菌病病因。
