Salmon Eric, Garraux Gaëtan, Delbeuck Xavier, Collette Fabienne, Kalbe Elke, Zuendorf Gerhard, Perani Daniela, Fazio Ferruccio, Herholz Karl
The Cyclotron Research Center, University of Liege, 4000 Liege, Belgium.
Neuroimage. 2003 Sep;20(1):435-40. doi: 10.1016/s1053-8119(03)00346-x.
In a multicenter study, FDG-PET images in a population of 29 patients with frontotemporal dementia (FTD) were compared to controls with similar age from each center. A conjunction analysis led to identification of the ventromedial frontopolar cortex as the single region affected in each and every FTD patients. This precise regional metabolic impairment should be integrated with recent neuropsychological researches, such as those showing that the ventromedial frontal cortex is critically involved in decision-making processes based on personal experience, feelings of rightness or social knowledge, processes that are characteristically impaired in FTD.
在一项多中心研究中，对29例额颞叶痴呆（FTD）患者群体的FDG-PET图像与来自每个中心的年龄相仿的对照组进行了比较。联合分析发现腹内侧额极皮层是每例FTD患者中唯一受影响的区域。这种精确的区域代谢损伤应与近期的神经心理学研究相结合，例如那些表明腹内侧前额叶皮层在基于个人经验、正确感或社会知识的决策过程中起关键作用的研究，而这些过程在FTD中通常会受损。
