Diehl J, Grimmer T, Drzezga A, Riemenschneider M, Förstl H, Kurz A
Department of Psychiatry, Technische Universität München, Munich, Germany.
Neurobiol Aging. 2004 Sep;25(8):1051-6. doi: 10.1016/j.neurobiolaging.2003.10.007.
To determine the patterns of cerebral glucose metabolism in frontotemporal dementia (FTD) and semantic dementia (SD).
25 patients with mild FTD and 9 patients with mild SD as well as 15 healthy age-matched control subjects underwent 18F-FDG- positron emission tomography. Patient scans were compared with control scans using SPM-99.
As compared with healthy control subjects patients with FTD showed an extensive symmetrical hypometabolism of the frontal lobes (height threshold P <0.01) which spared the motor cortex. Patients with SD showed a hypometabolism in the whole left temporal lobe and in the right temporal pole.
In the clinical syndromes of FTD and SD two distinct patterns of cerebral metabolism were identified. FTD was associated with frontal hypometabolism, whereas in SD cerebral glucose metabolism was exclusively reduced in the temporal lobes. Our findings are consistent with the notion that FTD and SD begin as strictly lobar neuronal degenerations and that a spread of pathological changes is not seen until more advanced stages.
确定额颞叶痴呆（FTD）和语义性痴呆（SD）的脑葡萄糖代谢模式。
25例轻度FTD患者、9例轻度SD患者以及15名年龄匹配的健康对照者接受了18F-FDG正电子发射断层扫描。使用SPM-99将患者的扫描结果与对照扫描结果进行比较。
与健康对照者相比，FTD患者表现出额叶广泛的对称性代谢减低（高度阈值P<0.01），运动皮质未受累。SD患者表现为整个左侧颞叶和右侧颞极代谢减低。
在FTD和SD的临床综合征中，确定了两种不同的脑代谢模式。FTD与额叶代谢减低有关，而在SD中，脑葡萄糖代谢仅在颞叶降低。我们的研究结果与以下观点一致，即FTD和SD始于严格的叶性神经元变性，并且直到更晚期阶段才会出现病理变化的扩散。
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