van Beek Nicole, Perna Giampaolo, Schruers Koen, Verburg Kees, Cucchi Michele, Bellodi Laura, Griez Eric
Maastricht University, Departmant of Psychiatry, PO Box 616, Maastricht 6200 MD, The Netherlands.
Psychiatry Res. 2003 Sep 30;120(2):125-30. doi: 10.1016/s0165-1781(03)00164-1.
Patients with panic disorder often report a history of respiratory pathology. Furthermore, panic disorder patients are vulnerable to CO2 challenges. The increased CO2 vulnerability displayed by panic disorder patients may be related to lifetime respiratory pathology. We examined whether panic disorder patients with a history of respiratory disorders are more vulnerable to a 35% CO2 challenge than those without such a history. Ninety-six patients with panic disorder were interviewed about their lifetime respiratory status (asthma, bronchitis and various other respiratory conditions) and underwent the challenge. Immediately before and after the CO2 inhalation, the patients filled out the Visual Analogue Scale for Anxiety (VAS-A) and the Panic Symptom List (PSL). We found no differences between the two panic disorder groups on anxiety (VAS-A), panic symptoms (PSL) or panic attacks after the CO2 challenge. Our results suggest that having a PD is an important factor in CO2 vulnerability independent of a history of respiratory disorders.
惊恐障碍患者常报告有呼吸道疾病史。此外，惊恐障碍患者对二氧化碳激发试验敏感。惊恐障碍患者表现出的对二氧化碳敏感性增加可能与终生呼吸道疾病有关。我们研究了有呼吸道疾病史的惊恐障碍患者是否比没有此类病史的患者更容易受到35%二氧化碳激发试验的影响。对96名惊恐障碍患者询问了其终生呼吸道状况（哮喘、支气管炎和各种其他呼吸道疾病）并进行了激发试验。在吸入二氧化碳之前和之后，患者填写焦虑视觉模拟量表（VAS-A）和惊恐症状清单（PSL）。我们发现在二氧化碳激发试验后，两组惊恐障碍患者在焦虑（VAS-A）、惊恐症状（PSL）或惊恐发作方面没有差异。我们的结果表明，患有惊恐障碍是二氧化碳敏感性的一个重要因素，与呼吸道疾病史无关。
