Verburg K, Pols H, de Leeuw M, Griez E
Department of Psychiatry and Neuropsychology, Academic Psychiatric Center, Maastricht University, The Netherlands.
Psychiatry Res. 1998 May 8;78(3):207-14. doi: 10.1016/s0165-1781(98)00009-2.
The objective of this study was to determine the test-retest reliability of the 35% carbon dioxide (CO2) panic provocation challenge. Thirty patients with panic disorder were included in this study. Twenty-four patients were challenged twice, with 1 week between the two challenges. Six patients dropped out after the first test. The 35% CO2 challenge appeared to have a good test-retest reliability; both on induced subjective anxiety, measured on a Visual Analogue Scale for Anxiety (VAS-A), and induced panic symptoms, measured with a Panic Symptom List. Assessing the state of anxiety immediately after the challenge gave the most reliable results. Calculating increase in anxiety from the pre- and post-scores on the VAS-A rendered less reliable scores. This study completes a series of studies in which the criteria for an ideal model of panic are tested for the 35% CO2 challenge. Apart from an absolute specificity for panic disorder, the challenge meets these criteria.
本研究的目的是确定35%二氧化碳（CO₂）惊恐激发试验的重测信度。本研究纳入了30名惊恐障碍患者。24名患者接受了两次激发试验，两次试验间隔1周。6名患者在首次测试后退出。35% CO₂激发试验似乎具有良好的重测信度；无论是在通过焦虑视觉模拟量表（VAS-A）测量的诱发主观焦虑方面，还是在通过惊恐症状清单测量的诱发惊恐症状方面。在激发试验后立即评估焦虑状态可得到最可靠的结果。通过VAS-A的前后得分计算焦虑增加量得到的分数可靠性较低。本研究完成了一系列研究，其中对35% CO₂激发试验的惊恐理想模型标准进行了测试。除了对惊恐障碍具有绝对特异性外，该激发试验符合这些标准。
