细菌AlkB蛋白介导的DNA修复
DNA repair by bacterial AlkB proteins.
作者信息
Falnes Pål Ø, Rognes Torbjørn
机构信息
Centre for Molecular Biology and Neuroscience and Institute of Medical Microbiology, University of Oslo, Rikshospitalet, 0027 Oslo, Norway.
出版信息
Res Microbiol. 2003 Oct;154(8):531-8. doi: 10.1016/S0923-2508(03)00150-5.
Abstract
The Escherichia coli AlkB protein is an iron- and 2-oxoglutarate-dependent oxygenase, repairing 1-methyladenine and 3-methylcytosine lesions in DNA. AlkB homologues are present in a number of bacterial species, and some bacteria have two different AlkB proteins. AlkB also repairs lesions in RNA, and the biological significance of RNA repair is discussed.
摘要
大肠杆菌AlkB蛋白是一种依赖铁和2-氧代戊二酸的加氧酶，可修复DNA中的1-甲基腺嘌呤和3-甲基胞嘧啶损伤。AlkB同源物存在于许多细菌物种中，一些细菌有两种不同的AlkB蛋白。AlkB还可修复RNA中的损伤，并对RNA修复的生物学意义进行了讨论。
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