Falnes Pål Ø, Rognes Torbjørn
Centre for Molecular Biology and Neuroscience and Institute of Medical Microbiology, University of Oslo, Rikshospitalet, 0027 Oslo, Norway.
Res Microbiol. 2003 Oct;154(8):531-8. doi: 10.1016/S0923-2508(03)00150-5.
The Escherichia coli AlkB protein is an iron- and 2-oxoglutarate-dependent oxygenase, repairing 1-methyladenine and 3-methylcytosine lesions in DNA. AlkB homologues are present in a number of bacterial species, and some bacteria have two different AlkB proteins. AlkB also repairs lesions in RNA, and the biological significance of RNA repair is discussed.
大肠杆菌AlkB蛋白是一种依赖铁和2-氧代戊二酸的加氧酶，可修复DNA中的1-甲基腺嘌呤和3-甲基胞嘧啶损伤。AlkB同源物存在于许多细菌物种中，一些细菌有两种不同的AlkB蛋白。AlkB还可修复RNA中的损伤，并对RNA修复的生物学意义进行了讨论。
