Freitas Tracey Allen K, Hou Shaobin, Alam Maqsudul
Department of Microbiology, Snyder Hall 207, 2538 The Mall, University of Hawaii, Honolulu, HI 96822, USA.
FEBS Lett. 2003 Sep 25;552(2-3):99-104. doi: 10.1016/s0014-5793(03)00923-2.
The recently discovered globin-coupled sensors (GCSs) are heme-containing two-domain transducers distinct from the PAS domain superfamily. We have identified an additional 22 GCSs with varying multi-domain C-terminal transmitters through a search of the complete and incomplete microbial genome datasets. The GCS superfamily is composed of two major subfamilies: the aerotactic and gene regulators. We postulate the existence of protoglobin in Archaea as the predecessor to the chimeric GCS.
最近发现的珠蛋白偶联传感器（GCSs）是含血红素的双结构域传感器，与PAS结构域超家族不同。通过搜索完整和不完整的微生物基因组数据集，我们鉴定出另外22种具有不同多结构域C末端信号传递器的GCSs。GCS超家族由两个主要亚家族组成：趋氧性和基因调节因子。我们推测古菌中存在原珠蛋白作为嵌合GCS的前身。
