Amir G, Pirie C J, Rashad S, Revell P A
Department of Morbid Anatomy, London Hospital Medical College.
J Clin Pathol. 1992 Nov;45(11):990-2. doi: 10.1136/jcp.45.11.990.
To determine whether remodelling of subchondral bone in osteoarthritis is related to anatomical and mechanical factors operating on the joint surface.
Ten femoral heads were examined. Patients due to have the femoral head removed because of osteoarthritis were given a double tetracycline label before surgery. The specimens were divided in three roughly equal parts, corresponding to the medial, central (weight bearing), and lateral aspects of the femoral heads. Undecalcified methylmethacrylate embedded sections were prepared. The subchondral bone was assessed for appositional bone formation by ultraviolet light microscopy, for resorptive activity by osteoclast count, and for trabecular bone volume by semiautomatic computerised image analysis. Appositional bone rate was also correlated with the presence or absence of overlying cartilage.
Bone density was reduced in the medial aspect of the femoral heads but there was no significant difference between the appositional bone rate or the resorptive activity in the three areas. Nor was there any correlation between appositional bone rate in the subchondral bone and the presence or absence of overlying cartilage.
Remodelling of subchondral bone in osteoarthritis, at least in the short term, is fairly constant and is not related to weight bearing.
确定骨关节炎中软骨下骨重塑是否与作用于关节表面的解剖学和力学因素相关。
检查了10个股骨头。因骨关节炎即将接受股骨头切除术的患者在手术前接受双四环素标记。标本大致分为三个相等的部分，分别对应股骨头的内侧、中央（负重）和外侧。制备未脱钙的甲基丙烯酸甲酯包埋切片。通过紫外线显微镜评估软骨下骨的贴壁骨形成，通过破骨细胞计数评估吸收活性，并通过半自动计算机图像分析评估小梁骨体积。贴壁骨率也与覆盖软骨的有无相关。
股骨头内侧的骨密度降低，但三个区域的贴壁骨率或吸收活性之间无显著差异。软骨下骨的贴壁骨率与覆盖软骨的有无之间也无任何相关性。
骨关节炎中软骨下骨的重塑，至少在短期内，相当恒定且与负重无关。
